Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction
Background and aimsWnt/β-catenin signaling plays an important role in regulating hepatic metabolism.This study is to explore the molecular mechanisms underlying the potential crosstalk between Wnt/β-catenin and mTOR signaling in hepatic steatosis.MethodsTransgenic mice (overexpress Wnt1 in hepatocytes, Wnt+) mice and wild-type littermates were gi